Pharmacy Study Material

Free pharmacy material Gout It is a disease characterized by elevated serum uric acid level. Uric acid has low water solubility and gets precipitated in the joints, kidney and subcutaneous . Secondary hyperuricemia may result due to excessive production (breakdown of proteins and nucleic acids during cancer chemotherapy) or decreased excretion (due to the use of thiazides, loop diuretics, ethambutol, clofibrate etc.) of uric acid. Acute gout It is manifested as severe inflammation of joints (due to precipitation of uric acid crystals) • NSAIDs like indomethacin are drug of choice due to better tolerability. Aspirin is not used as it may cause hyperuricemia. Tolmetin is not effective. • Colchicine is more effective and faster acting than NSAIDs but is used rarely due to its high toxicity. It acts by inhibiting granulocyte migration into the inflamed joint. It causes metaphase arrest (other drugs causing metaphase arrest are vinca alkaloids, ixabepilone and taxanes...