Pharmacy Study Material

Free pharmacy material Polarimetry INTRODUCTION Polarimetry is a sensitive non-destructive method for the measurement of the optical activity of the compounds which are organic or inorganic in nature. This measures the rotation of the polarized light as it passes through an optically active compound. This method i s mainly used in the determination of the unknown solution concentrations. A substance is said to be optically active if it rotates the plane of the polarized light. Optical activity phenomenon When the polarized light passes through the optically active substance and rotates the plane of polarized light to the left side, or clockwise, then the compound is known as the dextrorotatory substance. If the rotation is observed in the right side, or anti-clockwise direction, then the compound is known as the levorotatory substance. THEORY The rotation of the plane polarized light is mainly based upon the asymmetric molecules and the steric configuration...