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| Basic And Clinical Pharmacology Book by Bertram Katzung |
Free pharmacy material Diazotization Titrations INTRODUCTION The diazotization titration is nothing but the conversion of the primary aromatic amine to a diazonium compound. This process was first discovered in 1853 and was applied to the synthetic dye industry. The reaction mechanism was first proposed by Peter Griessin. In this method, the primary aromatic amine is reacted with the sodium nitrite in acidic medium to form a diazonium salt. This method is first used in the determination of dyes. PRINCIPLE The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt. R − NH 2 + NaNO 2 +HCl R − N + ≡ N − Cl − + NaCl + H 2 O Sodium nitrite is added to the solution of amine in the presence of acid at 0–5 °C. The amine reacts with the nitrous acid to form nitrosamine, which is followed by the tautomerisation and the water mol...