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Diuretics (Part -2) 3. Diuretics Acting on the Distal Tubules and Collecting Ducts ● Thiazides Drugs in this group include bendroflumethiazide, chlorthiazide, hydrochlorthiazide, methiclothiazide, polythiazide, trichlormethiazide, benzthiazide, hydroflumethiazide, chlorthalidone, metolazone, quinethazone and indapamide. These drugs act by inhibiting Na+-Cl– symporter at the luminal membrane of early DT. ● Potassium Sparing Diuretics These diuretics act in the late DT and CD cells to preserve K+. (a) Epithelial Na+ channel inhibitors These drugs are basic in nature and reach the lumen of PT by secretion through organic base secretory system. By travelling through the lumen, these drugs reach its site of action i.e. late DT and CD. Members of this group are amiloride and triamterene (b) Aldosterone antagonists Spironolactone, canrenone, potassium canreonate and epleronone antagonize the action of aldosterone and produce effects similar to amiloride. These drugs act from the interstitial site of tubular cel

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