Pharmacy Study Material

Free pharmacy material Particle Size Analysis INTRODUCTION Particle size is the physical property of the compound which influences the stability, solubility and processability. The unit for the particle size is micrometer (μm). There are different methods for the determination of the particle size, as follows: Microscopy Sieving method Sedimentation method Sensing zone method Light scattering method Surface area measurement method The selection of the method is mainly based upon the following: Nature of the compound Solubility Toxicity Flowability Cost Specifcation requirements, etc. Types of Diameters Martin's diameter: This is the length of the line which bisects the particle. Feret's diameter: this is the distance between the two tangents of the particle. Projected area diameter: this is the diameter of the circle having the same area as that of the particle. METHODS FOR PARTICLE SIZE ANALYSIS Microscopy T...