Pharmacy Study Material

Free pharmacy material Quinolone Antibacterials .1 INTRODUCTION Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. Quinolones are potent, broad-spectrum antibacterial agents. The early congeners (non-fluorinated at C-6 like nalidixic acid) were limited to certain gram-negative infections such as urinary tract infections. However, the modern generation of fluoroquinolones containing C-6 fluoro substituent and a cyclic basic amine moiety at C-7 surpass their predecessors in terms of spectrum of activity and potency. This has allowed for their use against a variety of gram-negative as well as some gram-positive pathogens. Quinolones are relatively easily prepared and easily administered via parenteral and oral routes, and are well tolerated. 25.2 STRUCTURES OF FLUOROQUINOLONES 25.3 MECHANISM OF ACTION Quinolones inhibit the action of b...