Pharmacy Study Material

Free pharmacy material \ Potentiometry INTRODUCTION In 1889, Nernst proposed an equation which states that the electrochemical cell potential is directly proportional to the concentration of the sample solution. In 1906, Cremer explained that the potential difference exists between the reference electrode and the indicator electrode. In 1909, pH electrode is developed for the measurement of the potential. Potentiometry is mainly used to determine the potential or the electromotive force of a sample solution. The potential is directly proportional to the concentration of the ions. The potential difference is determined by the electrochemical cell which is composed of pair of electrodes namely the indicator electrode and the reference electrode. PRINCIPLE The principle involved in the potentiometry is when the pair of electrodes is placed in the sample solution it shows the potential difference by the addition of the titrant or by the change in the concentration of the ions....