Pharmacy Study Material

Free pharmacy material Sulphonamides, Sulphones, and Dihydrofolate Reductase Inhibitors The sulphonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. The sulphonamides and sulphone antibacterials as well as the 2,4-diaminopyrimidine antifolates continue to be successful chemotherapeutic agents. 24.1 SULPHONAMIDES The sulphonamide drugs were the first effective chemotherapeutic agents to be employed systemically for the prevention of bacterial infections in human beings. These are totally synthetic substances that are produced by relatively simple chemical synthesis. Sulphonamide drugs are a group of synthetic antimicrobial drugs that have a broad spectrum of use with respect to grampositive as well as gram-negative micro-organisms. They were introduced into medical practice even before the discovery of penicillins. Sulphonamide drugs are derivatives of sulphanilamide. The advent of penicillin and s...